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Tuberculosis
Reports summarize tuberculosis study results from M. Srinivas and co-researchers
July 29th, 2008
"Mycobacterium tuberculosis survives and persists for prolonged periods within its host in an asymptomatic, latent state and can reactivate years later if the host's immune system weakens. The dormant bacilli synthesize and accumulate triacylglycerol, reputed to be an energy source during latency," investigators in Bangalore, India report. "Among the phospholipases, phospholipase C plays an important role in the pathogenesis. Mutations in a known phospholipase C,plcC, of M tuberculosis attenuate its growth during the late phase of infection in mice. Hydrolysis of phospholipids by phospholipase C generates diacylglycerol, a well-known signalling molecule that...
Source: TB & Outbreaks Week (2008-07-29)
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