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Tuberculosis
Research results from W. Frigui and colleagues update understanding of tuberculosis
July 29th, 2008
According to a study from Paris, France, "Analysis of mycobacterial strains that have lost their ability to cause disease is a powerful approach to identify yet unknown virulence determinants and pathways involved in tuberculosis pathogenesis. Two of the most widely used attenuated strains in the history of tuberculosis research are Mycobacterium bovis BCG ( BCG) and Mycobacterium tuberculosis H37Ra ( H37Ra), which both lost their virulence during in vitro serial passage." "Whereas the attenuation of BCG is due mainly to loss of the ESAT-6 secretion system, ESX-1, the reason why H37Ra is attenuated remained unknown. However, here we show that a point mutation (S219L) in...
Source: TB & Outbreaks Week (2008-07-29)
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