TB & Outbreaks Week
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of TB & Outbreaks Week
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Tuberculosis
Researchers at Yeshiva University, Medical Department target tuberculosis
July 29th, 2008
"The intrinsic resistance of Mycobacterium tuberculosis to the beta-lactam class of antibiotics arises from a chromosomally encoded, extended spectrum, class A beta-lactamase, BlaC," researchers in the United States report. "Herein, we report the X-ray crystallographic structure of BlaC inhibited with clavulanate at a resolution of 1.7 angstrom with an R-factor value of 0.180 and R-free value of 0.212 for the m/z + 154 clavulanate-derived fragment observed in the active site. Structural evidence reveals the presence of hydrogen bonds to the C1 carbonyl along with a coplanar arrangement of C1, C2, C3, and N4, which favors enolization to generate a trans-alpha,beta-...
Source: TB & Outbreaks Week (2008-07-29)
|
