TB & Outbreaks Week
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of TB & Outbreaks Week
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Tuberculosis
New findings from University of Texas in the area of tuberculosis published
August 5th, 2008
According to recent research from the United States, "Mycobacterium tuberculosis H37Rv (Mtb) excludes phagocyte oxidase (phox) and inducible nitric oxide synthase (iNOS) while preventing lysosomal fusion in macrophages (M Phi s). The antigen 85A deficient (Delta fbpA) mutant of Mtb was vaccinogenic in mice and the mechanisms of attenuation were compared with M Phi s infected with H37Rv and BCG." "Delta fbpA contained reduced amounts of trehalose 6, 6, dimycolate and induced minimal levels of SOCS-1 in M Phi s. Blockade of oxidants enhanced the growth of Delta fbpA in M Phi s that correlated with increased colocalization with phox and iNOS. Green fluorescent...
Source: TB & Outbreaks Week (2008-08-05)
|
