Enzyme Research
New enzyme research findings from Institute of Microbiology described
Published in TB and Outbreaks Week, August 5th, 2008
A new study, 'The Legionella autoinducer synthase LqsA produces an alpha-hydroxyketone signaling molecule,' is now available. "The opportunistic pathogen Legionella pneumophila replicates in human lung macrophages and in free-living amoebae. To accommodate the transfer between host cells, L. pneumophila switches from a replicative to a transmissive phase. L. pneumophila harbors a gene cluster homologous to the Vibrio cholerae cqsAS quorum sensing system, encoding a putative autoinducer synthase (lqsA) and a sensor kinase (lqsS), which flank a response regulator (lqsR)," investigators in Zurich, Switzerland report.
"LqsR is an element of the...
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