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Ebola Hemorrhagic Fever
Research from A.L. Hartman and co-authors yields new data on ebola hemorrhagic fever
August 12th, 2008
"Ebola hemorrhagic fever is a rapidly progressing acute febrile illness characterized by high virus replication, severe immunosuppression, and case fatalities of ca. 80%. Inhibition of phosphorylation of interferon regulatory factor 3 (IRF-3) by the Ebola VP35 protein may block the host innate immune response and play an important role in the severity of disease," researchers in the United States report. "We used two precisely defined reverse genetics-generated Ebola viruses to investigate global host cell responses resulting from the inhibition of IRF-3 phosphorylation. The two viruses encoded either wild-type (WT) VP35 protein (recEbo-VP35/WT) or VP35 with an arginine...
Source: TB & Outbreaks Week (2008-08-12)
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