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Leishmaniasis
Research from A. Poddar et al has provided new information about leishmaniasis
August 12th, 2008
"Bioactivity-guided fractionation has led to the successful isolation of calceolarioside A (1) from the methanolic extract of night jasmine leaves. The in vitro antileishmanial activity of compound 1 was determined (IC50=20 mu g/mL)," scientists in Calcutta, India report. "Its in vivo efficacy was noted at 20 mg/kg body weight when it reduced the hepatic and splenic parasite burden by 79 and 84%, respectively, in an established model of L. donovani Ag83 infected golden hamster. Furthermore, synergistic potentiations of compound 1 at 20 mg/kg body weight and SAG at 5 mg/kg body weight showed a significant reduction of hepatic and splenic parasite burden. No cytotoxicity...
Source: TB & Outbreaks Week (2008-08-12)
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