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Paramyxovirus
New paramyxovirus study results reported from Cleveland Clinic
August 12th, 2008
According to recent research published in the Journal of Biological Chemistry, "V accessory proteins from Paramyxoviruses are important in viral evasion of the innate immune response. Here, using a cell survival assay that identifies both inhibitors and activators of interferon regulatory factor 3 (IRF3)-mediated gene induction, we identified select paramyxoviral V proteins that inhibited double-stranded RNA- mediated signaling; these are encoded by mumps virus ( MuV), human parainfluenza virus 2 ( hPIV2), and parainfluenza virus 5 ( PIV5), all members of the genus Rubulavirus." "We showed that interaction between V and the IRF3/7 kinases, TRAF family...
Source: TB & Outbreaks Week (2008-08-12)
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