TB & Outbreaks Week
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Tuberculosis
Findings from E.M. Agger et al in tuberculosis reported
August 12th, 2008
"It is known that protection against tuberculosis is mediated primarily by T helper type 1 (Th1) cells but the influence of the Th1/Th2 balance of a vaccination response on the subsequent protection and pathology during infection has not been studied in detail. We designed a panel of Ag85B-ESAT-6 subunit vaccines based on adjuvants with different Th1/Th2-promoting activities and studied cellular responses, bacterial replication and pathology in the lungs of mice infected with Mycobacterium tuberculosis," scientists in Copenhagen, Denmark report. "All vaccines induced cell-mediated and humoral responses but with markedly different interferon-gamma : interleukin-5...
Source: TB & Outbreaks Week (2008-08-12)
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