TB & Outbreaks Week
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Tuberculosis
Reports from G.S. Rao et al highlight recent research in tuberculosis
August 12th, 2008
"In an attempt to design novel anti-TB drugs, the target chosen is the enzyme 6-hydroxymethyl-7,8-dihydropteroate synthase (DHPS), which is an attractive target since it is present in microorganisms but not in humans. The existing drugs for this target are the sulfa drugs, which have been used for about seven decades," scientists in New Delhi, India report. "However, single mutations in the DHPS gene can cause resistance to sulfa drugs. Therefore, there is a need for the design of novel drugs. Based on the recently determined crystal structure of Mycobacterium tuberculosis (M.tb) DHPS complexed with a known substrate analogue, and on the crystal structures of E. coli...
Source: TB & Outbreaks Week (2008-08-12)
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