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Tuberculosis
Research from Texas A&M University provide new insights into tuberculosis
August 12th, 2008
"Phosphoribosyl-ATP pyrophosphohydrolase is the second enzyme in the histidine-biosynthetic pathway, irreversibly hydrolyzing phosphoribosyl-ATP to phosphoribosyl-AMP and pyrophosphate. It is encoded by the hisE gene, which is present as a separate gene in many bacteria and archaea but is fused to hisI in other bacteria, fungi and plants," scientists writing in the journal Acta Crystallographica Section D - Biological Crystallography report. "Because of its essentiality for growth in vitro, HisE is a potential drug target for tuberculosis. The crystal structures of two native (uncomplexed) forms of HisE from Mycobacterium tuberculosis have been determined to...
Source: TB & Outbreaks Week (2008-08-12)
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