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TB & Outbreaks Week

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Escherichia Coli



Researchers at University of Oklahoma target Escherichia coli



August 19th, 2008

"Mutant screens and transcriptome studies led us to consider whether the metabolism of glucose polymers, i.e., maltose, maltodextrin, and glycogen, is important for Escherichia coli colonization of the intestine. By using the streptomycin-treated mouse model, we found that catabolism of the disaccharide maltose provides a competitive advantage in vivo to pathogenic E. coli O157:H7 and commensal E. coli K-12, whereas degradation of exogenous forms of the more complex glucose polymer, maltodextrin, does not," scientists in the United States report.

"The endogenous glucose polymer, glycogen, appears to play an important role in colonization, since mutants that are unable...


Source: TB & Outbreaks Week (2008-08-19)

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