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Granuloma
Studies from National Institutes of Health describe new findings in granuloma
August 19th, 2008
"Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic processes to shorten drug regimens. Pimonidazole hydrochloride (Hypoxyprobe) is an imaging agent that is bioreductively activated only under hypoxic conditions in mammalian tissue," scientists writing in the journal Infection and Immunity report. "We employed this probe to evaluate the oxygen tension in tuberculous granulomas in four animal models of disease: mouse, guinea pig, rabbit, and nonhuman primate. Following infusion of pimonidazole into animals with established infections,...
Source: TB & Outbreaks Week (2008-08-19)
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