TB & Outbreaks Week
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Inhibitory Peptides
Studies from N.R. Silvaggi et al have provided new data on inhibitory peptides
August 19th, 2008
According to recent research from the United States, "The Clostridium botulinum neurotoxin serotype A light chain (BoNT/A-LC) is a Zn(II)dependent metalloprotease that blocks the release of acetylcholine at the neuromuscular junction by cleaving SNAP-25, one of the SNARE proteins required for exocytosis. Because of the potential for use of the toxin in bioterrorism and the increasingly widespread application of the toxin in the medical field, there is significant interest in the development of small-molecule inhibitors of the metalloprotease." "Efforts to design such inhibitors have not benefited from knowledge of how peptides bind to the active site since the...
Source: TB & Outbreaks Week (2008-08-19)
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