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Leishmaniasis
Studies from University of North Carolina, Medical Department provide new data on leishmaniasis
August 19th, 2008
"Old World cutaneous leishmaniasis is caused by infection with Leishmania major and Leishmania tropica. Pentamidine and related dications exhibit broad spectrum antiprotozoal activity," researchers in the United States report. "Based on the previously reported efficacy of these compounds against related organisms, 18 structural analogs of pentamidine were evaluated for in vitro antileishmanial activity, using pentamidine as the standard reference drug for comparison. Furan analogs and reversed amidine compounds were examined for activity against L. major and L. tropica promastigotes. The most active compounds against both Leishmania species were in the reversed amidine...
Source: TB & Outbreaks Week (2008-08-19)
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