TB & Outbreaks Week
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Life Sciences
Study results from University of Sao Paulo update understanding of life sciences
August 19th, 2008
According to recent research from Sao Carlos, Brazil, "Leishmaniasis and trypanosomiasis are major causes of morbidity and mortality in both tropical and subtropical regions of the world. The current available drugs are limited, ineffective, and require long treatment regimens." "Due to the high dependence of trypanosomatids on glycolysis as a source of energy, some glycolytic enzymes have been identified as attractive targets for drug design. In the present work, classical Two-Dimensional Quantitative Structure -Activity Relationships (2D QSAR) and Hologram QSAR (HQSAR) studies were performed on a series of adenosine derivatives as inhibitors of Leishmania mexicana...
Source: TB & Outbreaks Week (2008-08-19)
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