TB & Outbreaks Week
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Tuberculosis
Data on tuberculosis published by researchers at Wadsworth Center
August 19th, 2008
"Little is known about how Mycobacterium tuberculosis regulates gene expression in response to its host environment, despite its importance as a pathogen. We previously characterized 10 acr-coregulated genes (ACGs), all of which belong to the DevR (DosR) ''dormancy'' regulon, and identified one to three copies of a conserved 18-bp palindromic DNA motif in the promoter of each ACG family member," investigators in the United States report. "In the present study, we used base substitution analyses to assess the importance of individual motif copies and to identify additional regulatory sequences in five ACG promoters. Regulation of acr, acg, Rv2623, narK2, and Rv1738 was...
Source: TB & Outbreaks Week (2008-08-19)
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