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Tuberculosis
New tuberculosis study findings have been reported by researchers at Johns Hopkins University
August 19th, 2008
"During human latent tuberculosis ( TB) infection, dormant bacilli putatively reside within the hypoxic environment of caseating lung granulomas. The anaerobic drug metronidazole has antituberculous activity under hypoxic conditions in vitro but lacks activity against murine TB," scientists writing in the Journal of Infectious Diseases report. "In the present study, we used the hypoxia marker pimonidazole to demonstrate the presence of hypoxia in a novel in vivo granuloma model of Mycobacterium tuberculosis latency. We also used a high-throughput, microarray-based technique to identify mycobacterial genes essential to hypoxia and showed that this in vivo model...
Source: TB & Outbreaks Week (2008-08-19)
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