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Tuberculosis
Reports from University of Birmingham add new data to research in tuberculosis
August 19th, 2008
"Mycobacterium tuberculosis and Corynebacterium glutamicum share a similar cell wall structure and orthologous enzymes involved in cell wall assembly. Herein, we have studied C. glutamicum NCgl1505, the orthologue of putative glycosyltransferases Rv1459c from M. tuberculosis and MSMEG3120 from Mycobacterium smegmatis," researchers in Birmingham, the United Kingdom report. "Deletion of NCgl1505 resulted in the absence of lipomannan (Cg-LM-A), lipoarabinomannan (Cg-LAM) and a multi-mannosylated polymer (Cg-LM-B) based on a 1,2-di-O-C-16/C-18:1-(alpha-D-glucopyranosyluronic acid)-(1 -> 3)-glycerol (GlcAGroAc(2)) anchor, while syntheses of...
Source: TB & Outbreaks Week (2008-08-19)
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