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Life Sciences
Investigators at Washington University publish new data on life sciences
August 26th, 2008
"The structure of the C-terminal domain of the mechanosensitive channel of large conductance (MscL) has generated significant controversy," investigators in the United States report. "As a result, several structures have been proposed for this region: the original crystal structure (1MSL) of the Mycobacterium tuberculosis homolog (Tb), a model of the Escherichia coli homolog, and, most recently, a revised crystal structure of Tb-MscL (2OAR). To understand which of these structures represents a physiological conformation, we measured the impact of mutations to the C-terminal domain on the thermal stability of Tb-MscL using circular dichroism and performed molecular...
Source: TB & Outbreaks Week (2008-08-26)
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