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Tuberculosis
New tuberculosis study findings have been reported by H. Safi and co-researchers
August 26th, 2008
"Implicated as a major mechanism of ethambutol (EMB) resistance in clinical studies of Mycobacterium tuberculosis, mutations in codon 306 of the embB gene (embB306) have also been detected in EMB-susceptible clinical isolates. Other studies have found strong associations between embB306 mutations and multidrug resistance, but not EMB resistance," researchers in the United States report. "We performed allelic exchange studies in EMB-susceptible and EMB-resistant clinical H. tuberculosis isolates to identify the role of embB306 mutations in any type of drug resistance. Replacing wild-type embB306 ATG from EMB-susceptible clinical M. tuberculosis strain 210 with embB306...
Source: TB & Outbreaks Week (2008-08-26)
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