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Tuberculosis
Research from J.J. Wilkins and co-researchers provides new data on tuberculosis
August 26th, 2008
According to a study from Observatory, South Africa, "This article describes the population pharmacokinetics of rifampin in South African pulmonary tuberculosis patients. Three datasets containing 2,913 rifampin plasma concentration-time data points, collected from 261 South African pulmonary tuberculosis patients aged 18 to 72 years and weighing 28.5 to 85.5 kg and receiving regular daily treatment that included administration of rifampin (450 to 600 mg) for at least 10 days, were pooled." "A compartmental pharmacokinetic model was developed using nonlinear mixed-effects modeling. Variability in the shape of the absorption curve was described using a flexible transit...
Source: TB & Outbreaks Week (2008-08-26)
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