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TB & Outbreaks Week

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Tuberculosis



Researchers at University of Michigan, Medical Department release new data on tuberculosis



August 26th, 2008

According to recent research from the United States, "During most infections, the population of immune cells known as macrophages are key to taking up and killing bacteria as an integral part of the immune response. However, during infection with Mycobacterium tuberculosis (Mtb), host macrophages serve as the preferred environment for mycobacterial growth."

"Further, killing of Mtb by macrophages is impaired unless they become activated. Activation is induced by stimulation from bacterial antigens and inflammatory cytokines derived from helper T cells. The key macrophage-activating cytokines in Mtb infection are tumor necrosis factor-alpha (TNF) and interferon...


Source: TB & Outbreaks Week (2008-08-26)

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