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Influenza
Study findings from M.L. Mihajlovic et al broaden understanding of influenza
September 2nd, 2008
"In the context of a recent pandemic threat by the worldwide spread of H5N1 avian influenza, the high resistance of H5N1 virus to the most widely used commercial drug, oseltarnivir (Tamiflu), is currently an important research topic. Herein, molecular bases of the mechanism of H5N1 NA resistance to orseltarnivir were elucidated using a computational approach in a systematic fashion," scientists in Serbia report. "Using the crystal structure of the complex of H5N1 NAwith OTV (PDB ID: 2hu0) as the starting point, the question, how mutations at His274 by both smaller side chain (Gly, Set, Asn, Gln) and larger side chain (Phe, Tyr) residues influence the sensitivity of N1...
Source: TB & Outbreaks Week (2008-09-02)
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