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TB & Outbreaks Week

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Leishmaniasis



Studies from National Institute of Allergy and Infectious Diseases have provided new information about leishmaniasis



September 2nd, 2008

"Visceral leishmaniasis (VL) is a fatal disease for humans, and no vaccine is currently available. Sand fly salivary proteins have been associated with protection against cutaneous leishmaniasis," scientists writing in the journal Proceedings of the National Academy of Sciences of the United States of America report.

"To test whether vector salivary proteins can protect against VL, a hamster model was developed involving intradermal inoculation in the ears of 100,000 Leishmania infantum chagasi parasites together with Lutzomyia longipalpis saliva to mimic natural transmission by sand flies. Hamsters developed classical signs of VL rapidly, culminating in a fatal...


Source: TB & Outbreaks Week (2008-09-02)

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