TB & Outbreaks Week
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Tuberculosis
Report summarizes tuberculosis study findings from University of California
September 2nd, 2008
According to a study from the United States, "Bacterial pathogens trigger specialized virulence factor secretion systems on encountering host cells. The ESX-1 protein secretion system of Mycobacterium tuberculosis - the causative agent of the human disease tuberculosis - delivers bacterial proteins into host cells during infection and is critical for virulence, but how it is regulated is unknown." "Here we show that EspR (also known as Rv3849) is a key regulator of ESX-1 that is required for secretion and virulence in mice. EspR activates transcription of an operon that includes three ESX-1 components, Rv3616c-Rv3614c, whose expression in turn promotes secretion of...
Source: TB & Outbreaks Week (2008-09-02)
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