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Tuberculosis
Research from University of Auckland in tuberculosis provides new insights
September 2nd, 2008
According to recent research from Auckland, New Zealand, "The modified flavin coenzyme F-420 is found in a restricted number of microorganisms. It is widely distributed in mycobacteria, however, where it is important in energy metabolism, and in Mycobacterium tuberculosis (Mtb) is implicated in redox processes related to non-replicating persistence." "In Mtb, the F-420-dependent glucose-6-phosphate dehydrogenase FGD1 provides reduced F-420 for the in vivo activation of the nitroimidazopyran prodrug PA-824, currently being developed for anti-tuberculosis therapy against both replicating and persistent bacteria. The structure of M. tuberculosis FGD1 has been determined by...
Source: TB & Outbreaks Week (2008-09-02)
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