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Tuberculosis
Research on tuberculosis published by scientists at University of Paris
September 9th, 2008
According to a study from Paris, France, "Our understanding of the mechanisms used by Mycobacterium tuberculosis to persist in a ''dormant'' state is essential to the development of therapies effective in sterilizing tissues. Gene expression profiling in model systems has revealed a complex adaptive response thought to endow M. tuberculosis with the capacity to survive several months of combinatorial antibiotic treatment." "We show here that this adaptive response may involve remodeling of the peptidoglycan network by substitution of 4 -> 3 cross-links generated by the D,D-transpeptidase activity of penicillin-binding proteins by 3 -> 3 cross-links generated by a...
Source: TB & Outbreaks Week (2008-09-09)
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