TB & Outbreaks Week
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Life Sciences
Recent studies by A.K. Hirsch and co-authors add new data to life sciences findings
September 9th, 2008
Current study results from the report, 'Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis,' have been published. "Enzymes of the non-mevalonate pathway for isoprenoid biosynthesis are therapeutic targets for the treatment of important infectious diseases. Whereas this pathway is absent in humans, it is used by plants, many eubacteria and apicomplexan protozoa, including major human pathogens such as Plasmodium falciparum and Mycobacterium tuberculosis," scientists in Zurich, Switzerland report. "Herein, we report on the design, preparation and biological evaluation of a new series of ligands for IspE protein,...
Source: TB & Outbreaks Week (2008-09-09)
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