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Hemorrhagic Fever
Studies in the area of hemorrhagic fever reported from J.M. Rojek and co-researchers
September 9th, 2008
"The cellular proprotein convertase site I protease (SIP) has been implicated in the proteolytic processing of the glycoproteins (GPs) of Old World arenaviruses. Here we report that SIP is also involved in the processing of the GPs of the genetically more-distant South American hemorrhagic fever viruses Guanarito, Machupo, and Junin," scientists writing in the Journal of Virology report. "Efficient cleavage of Guanarito virus GP, whose protease recognition sites deviate from the reported SIP consensus sequence, indicates a broader specificity of SIP than anticipated. Lack of GP processing of Junin virus dramatically reduced production of infectious virus and...
Source: TB & Outbreaks Week (2008-09-09)
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