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HIV/AIDS
New HIV/AIDS study findings have been reported by N. Dessallew and co-researchers
September 16th, 2008
According to recent research from Addis Ababa, Ethiopia, "Chemokines receptors have emerged as important drug targets for the development of agents against the Human Immunodeficiency Virus (HIV)/AIDS pandemic. With the purpose of designing new chemical entities with enhanced antiretroviral potencies, the Quantitative Structure -Activity Relationships (QSAR) study carried out on 122 novel piperidin-4-carboxamide derivatives as antagonists of HIV Chemokine Receptor 5 (CCR5) coreceptor binding is presented." "The developed model was validated by standard QSAR parameters and through a detailed structural investigation on how it explains and reproduces the quantitative...
Source: TB & Outbreaks Week (2008-09-16)
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