TB & Outbreaks Week
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Life Sciences
Study results from University of Utah, Medical Department provide new insights into life sciences
September 16th, 2008
According to a study from the United States, "Many intracellular pathogens infect macrophages and these pathogens require iron for growth. Here we demonstrate in vitro that the intracellular growth of Chlamydia psittaci, trachomatis, and Legionella pneumophila is regulated by the levels of intracellular iron." "Macrophages that express cell surface ferroportin, the only known cellular iron exporter, limit the intracellular growth of these bacteria. Hepcidin is an antimicrobial peptide secreted by the liver in response to inflammation. Hepcidin binds to ferroportin mediating its internalization and degradation. Addition of hepcidin to infected macrophages enhanced the...
Source: TB & Outbreaks Week (2008-09-16)
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