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Tuberculosis
Research from O.H. Vandal and co-authors yields new data on tuberculosis
September 16th, 2008
According to recent research from the United States, "Acidification of the phagosome is considered to be a major mechanism used by macrophages against bacteria, including Mycobacterium tuberculosis (Mtb). Mtb blocks phagosome acidification(1), but interferon-g (IFN-g) restores acidification and confers antimycobacterial activity2,3." "Nonetheless, it remains unclear whether acid kills Mtb, whether the intrabacterial pH of any pathogen falls when it is in the phagosome and whether acid resistance is required for mycobacterial virulence. In vitro at pH 4.5, Mtb survived in a simple buffer and maintained intrabacterial pH. Therefore, Mtb resists phagolysosomal...
Source: TB & Outbreaks Week (2008-09-16)
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