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Tuberculosis
Researchers at University of Auckland target tuberculosis
September 16th, 2008
"Folate derivatives are essential vitamins for cell growth and replication, primarily because of their central role in reactions of one-carbon metabolism. Folates require polyglutamation to be efficiently retained within the cell and folate-dependent enzymes have a higher affinity for the polyglutamylated forms of this cofactor," scientists writing in the journal Acta Crystallographica Section D - Biological Crystallography report. "Polyglutamylation is dependent on the enzyme folylpolyglutamate synthetase (FPGS), which catalyzes the sequential addition of several glutamates to folate. FPGS is essential for the growth and survival of important bacterial species,...
Source: TB & Outbreaks Week (2008-09-16)
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