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West Nile Virus
Study data from H.P. Dong and colleagues update understanding of west nile virus
September 16th, 2008
"West Nile virus methyltransferase catalyzes N7 and 2'-O methylations of the viral RNA cap (GpppA-RNA -> m(7)GpppAm-RNA). The two methylation events are independent, as evidenced by efficient N7 methylation of GpppA-RNA -> m(7)GpppA-RNA and GpppAm-RNA -> m(7)GpppAm-RNA, and by the 2'-O methylation of GpppA-RNA -> GpppAm-RNA and m(7)GpppA-RNA -> m(7)GpppAm-RNA," scientists writing in the journal Virology report. "However, the 2'-O methylation activity prefers substrate m(7)GpppA-RNA to GpppA-RNA, thereby determining the dominant methylation pathway as GpppARNA -> m(7)GpppA-RNA -> m(7)GpppAm-RNA. Mutant enzymes with different methylation...
Source: TB & Outbreaks Week (2008-09-16)
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