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Central Nervous System Disorders
Research conducted at Innsbruck Medical University has updated our knowledge about central nervous system disorders
September 16th, 2008
According to a study from Innsbruck, Austria, "The characteristic elevation of plasma glycine concentrations observed in propionic acidaemia (PA) and other 'ketotic hyperglycinaemias' has been attributed to secondary inhibition of the hepatic glycine cleavage system (GCS) by accumulating CoA derivatives of branched-chain amino acid metabolites. In nonketotic hyperglycinaemia (NKH), cerebrospinal fluid (CSF) and plasma glycine levels and their ratio are increased due to primary deficiency of central nervous system (CNS) as well as hepatic GCS." "Whether the GCS in the CNS is also inhibited in PA is unclear, as there are scant data available on CSF glycine levels in this...
Source: TB & Outbreaks Week (2008-09-16)
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