TB & Outbreaks Week
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Tuberculosis
Studies from University of Michigan, Medical Department update current data on tuberculosis
September 23rd, 2008
"Several molecules related to antigen presentation, including gamma interferon (IFN-gamma) and the major histocompatibility complex (MHC), are encoded by polymorphic genes. Some polymorphisms were found to affect susceptibility to tuberculosis (TB) when they were considered singly in epidemiological studies, but how multiple polymorphisms interact to determine susceptibility to TB in an individual remains an open question," researchers in the United States report. "We hypothesized that polymorphisms in some genes may counteract or intensify the effects of polymorphisms in other genes. For example, an increase in IFN-gamma expression may counteract the weak binding that...
Source: TB & Outbreaks Week (2008-09-23)
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