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Tuberculosis
New tuberculosis data have been reported by researchers at Medical University of Vienna
September 30th, 2008
"We describe the physiological function of heterologously expressed Mycobacterium tuberculosis InhA during de novo lipoic acid synthesis in yeast (Saccharomyces cerevisiae) mitochondria. InhA, representing 2-trans-enoyl-acyl carrier protein reductase and the target for the front-line antituberculous drug isoniazid, is involved in the activity of dissociative type 2 fatty acid synthase (FASH) that extends associative type I fatty acid synthase (FASI)-derived C-20, fatty acids to form C-60-to-C-90 mycolic acids," scientists in Vienna, Austria report. "Mycolic acids are major constituents of the protective layer around the pathogen that contribute to virulence and...
Source: TB & Outbreaks Week (2008-09-30)
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