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Tuberculosis
Studies from P. Selvaraj and colleagues provide new data on tuberculosis
September 30th, 2008
"Vitamin D receptor (VDR) gene variants are shown to regulate immune response in tuberculosis. We studied the influence of VDR promoter (Cdx-2 and A1012G), 3' untranslated region (Apa I, Bsm I, and Taq I) and start codon (Fok I) polymorphisms on 1,25(OH)(2)D-3-modulated IL-12p40, IFN-gamma, IL-10, and IL-5 response to live Mycobacterium tuberculosis and its culture filtrate antigen (CFA) in 60 normal healthy subjects and 51 pulmonary tuberculosis patients," scientists writing in the Journal of Clinical Immunology report. "In peripheral blood mononuclear cell cultures with CFA and 1,25(OH)(2)D-3, IL-12p40, and IFN-gamma levels were significantly decreased (p...
Source: TB & Outbreaks Week (2008-09-30)
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