TB & Outbreaks Week
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Life Sciences
Research from University of Minnesota provides new data on life sciences
October 7th, 2008
"Murine models of tuberculous meningitis (TBM) have not reflected the severity of disease in humans," investigators in the United States report. "Based on reports that activated murine microglial cells, but not human microglial cells, express inducible nitric oxide synthase (iNOS), the objective of this study was to determine whether iNOS- knockout (iNOS (-/-)) mice would provide such a model. iNOS (-/-) mice infected with M. tuberculosis developed serious clinical manifestations and granulomatous lesions containing tubercle bacilli throughout the meninges, all of which were absent in wild- type mice," wrote M.R. Olin and colleagues, University of Minnesota. ...
Source: TB & Outbreaks Week (2008-10-07)
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