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West Nile Virus
Report summarizes west nile virus study findings from Wadsworth Center
October 7th, 2008
According to recent research from the United States, "Flavivirus methyltransferase catalyzes both guanine N7 and ribose 2'-OH methylations of the viral RNA cap (GpppA-RNA -> m(7)GpppAm-RNA). The methyltransferase is physically linked to an RNA-dependent RNA polymerase (RdRp) in the flaviviral NS5 protein." "Here, we report genetic interactions of West Nile virus (WNV) methyltransferase with the RdRp and the 5'-terininal stem-loop of viral genomic RNA. Genome-length RNAs, containing amino acid substitutions of D146 (a residue essential for both cap methylations) in the methyltransferase, were transfected into BHK-21 cells. Among the four mutant RNAs (D146L, D146P,...
Source: TB & Outbreaks Week (2008-10-07)
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