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Legionnaire Disease
Researchers at Charite University target legionnaire disease
October 14th, 2008
"Legionella pneumophila causes severe pneumonia. Acetylation of histones is thought to be an important regulator of gene transcription, but its impact on L pneumophila-induced expression of proinflammatory cytokines is unknown. L. pneumophild strain 130b induced the expression of the important chemoattractant IL-8 and genome-wide histone modifications in human lung epithelial A549 cells," investigators in Berlin, Germany report. "We analyzed the IL-8-promoter and found that histone H4 was acetylated and H3 was phosphorylated at Ser(10) and acetylated at Lys(14), followed by transcription factor NF-kappa B. Recruitment of RNA polymerase II to the IL-8 promoter...
Source: TB & Outbreaks Week (2008-10-14)
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