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Mycobacteria
Studies by W. Weber and co-authors describe new findings in mycobacteria
October 14th, 2008
"Synthetic biology provides insight into natural gene-network dynamics and enables assembly of engineered transcription circuitries for production of difficult-to-access therapeutic molecules. In Mycobacterium tuberculosis EthR binds to a specific operator (O-ethR) thereby repressing ethA and preventing EthA-catalyzed conversion of the prodrug ethionamide, which increases the resistance of the pathogen to this last-line-of-defense treatment," scientists in Basel, Switzerland report. "We have designed a synthetic mammalian gene circuit that senses the EthR-O-ethR interaction in human cells and produces a quantitative reporter gene expression readout. Challenging of the...
Source: TB & Outbreaks Week (2008-10-14)
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