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Plague
Researchers at Yale University have published new data on plague
October 14th, 2008
According to a study from the United States, "External guide sequences (EGSs) targeting virulence genes from Yersinia pestis were designed and tested in vitro and in vivo in Escherichia coli." "Linear EGSs and M1 RNA-linked EGSs were designed for the yscN and yscS genes that are involved in type III secretion in Y. pestis," wrote J.H. Ko and colleagues, Yale University. The researchers concluded: "RNase P from E. coli cleaves the messages of yscN and yscS in vitro with the cognate EGSs, and the expression of the EGSs resulted in the reduction of the levels of these messages of the virulence genes when those genes were expressed in E. coli." ...
Source: TB & Outbreaks Week (2008-10-14)
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