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Tuberculosis
Recent findings from Osaka University highlight research in tuberculosis
October 14th, 2008
"In the course of our search for anti-microbial agents against dormant Mycobacterium tuberculosis, halicyclamine A was re-discovered as a lead for anti-tuberculosis agent from a marine sponge of Haliclona sp. on the guidance of the constructed bioassay. Halicyclamine A showed growth inhibition against Mycobacterium smegmatis, Mycobacterium bovis BCG, and M. tuberculosis H37Ra with MICs in the range of 1.0-5.0 mu g/ml under both aerobic condition and hypoxic condition inducing dormant state," investigators in Suita, Japan report. "The growth-inhibitory activity of halicyclamine A was bactericidal, and halicyclamine A did not exhibit cross-resistance with the currently...
Source: TB & Outbreaks Week (2008-10-14)
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