TB & Outbreaks Week
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of TB & Outbreaks Week
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Tuberculosis
Research data from D. Dube and colleagues update understanding of tuberculosis
October 14th, 2008
According to a study from Lucknow, India, "NAD(+)-dependent DNA ligases (LigA) are essential enzymes found only in bacteria and some virus species. This makes them attractive drug targets." "Based on the crystal structure of the NAD(+) binding domain of the M. tuberculosis enzyme (MtuLigA) and virtual screening, we have earlier identified several novel classes of inhibitors for this enzyme. These inhibitors bind to the adenylation domain and compete with the cofactor NAD(+). Recently, we identified that the BRCT domain is essential for the enzyme activity of MtuLigA. We have used virtual screening to identify compounds from the CAP database that should potentially bind...
Source: TB & Outbreaks Week (2008-10-14)
|
