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Tuberculosis
Studies from D. Dube and co-researchers in the area of tuberculosis published
October 14th, 2008
According to recent research published in the journal Medicinal Chemistry Research, "M. tuberculosis lysine epsilon-aminotransferase (MtbLAT) is a protein involved in lysine catabolism that belongs to the aminotransferase family of enzymes, which use pyridoxal 5'-phosphate (PLP) as a cofactor. It is implicated in mycobacterial stress response and is upregulated approximately 40-fold in nutrient-starved models designed to mimic the persistent/latent state of tuberculosis." "These studies seem to suggest an important role for MtbLAT in adaptation to long-term persistence in M. tuberculosis. Using the MtbLAT crystal structure, solved by us earlier, we generated a...
Source: TB & Outbreaks Week (2008-10-14)
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