Arenavirus

Research on arenavirus reported by J.M. Rojek et al

Published in TB and Outbreaks Week, October 14th, 2008

According to recent research from Lausanne, Switzerland, "The Old World arenavirus Lassa virus (LASV) is the causative agent of severe viral hemorrhagic fever (VHF) in humans and is the most prevalent human pathogen among arenaviruses. The present study investigated the largely unknown mechanisms of cell entry of LASV, a process know to be mediated solely by the virus envelope glycoprotein (GP)."

"To circumvent biosafety restrictions associated with the use of live LASV, we used reverse genetics to generate a recombinant variant of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) expressing the LASV GP (rLCMV-LASVGP). The rescued rLCMV-LASVGP grew to...

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Source: TB and Outbreaks Week (2008-10-14)

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