TB & Outbreaks Week
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Tuberculosis
Data on tuberculosis described by researchers at Chungnam National University, Medical Department
October 21st, 2008
According to recent research from South Korea, "Membrane lipid rafts are enriched in cholesterol and play an important role as signalling platforms. However, the roles of lipid rafts and associated signalling molecules in the innate immune responses to mycobacteria remain unknown." "Here we show that stimulation with Mycobacterium tuberculosis 19 kDa lipoprotein, a TLR2/1 agonist, results in translocation of TLR2 to lipid rafts, coalescence of lipid rafts and production of reactive oxygen species (ROS) that drive pro-inflammatory responses. Disruption of lipid raft organization markedly reduced lipoprotein-induced ROS and inflammatory responses. Remarkably, the atypical...
Source: TB & Outbreaks Week (2008-10-21)
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