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Central Nervous System Infection Immunology
Studies from Ludwig-Maximilians University, Department of Neurology further understanding of central nervous system infection immunology
October 21st, 2008
A report, 'Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4,' is newly published data in The Journal of Infectious Diseases. "Recent studies have suggested that, in addition to Toll-like receptor (TLR) 2, other pattern recognition receptors mediate activation of the immune response after infection of the central nervous system (CNS) with Streptococcus pneumoniae (SP). Using a mouse meningitis model, we investigated the influence of TLR4 single deficiency (TLR4(-/-)), TLR2/TLR4 double deficiency (TLR2/4(-/-)), and TLR2/TLR4/TLR9 triple deficiency (TLR2/4/9(-/-)) on the immune response of the CNS to SP...
Source: TB & Outbreaks Week (2008-10-21)
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